Published Scientific Papers on Thujone
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Pharmacology and toxicology of absinthe
By Jirí Patocka a and Bohumil Plucarb
Published in Journal of Applied Biomedicine, Vol 1, 2003
Abstract
Absinthe is a flavoured distilled liquor, emerald green in colour, turning to cloudy, opalescent white when mixed with water. It has
inspired many prominent artists, writers and poets – Vincent Van Gogh, Oscar Wilde, Pablo Picasso and Ernest Hemingway just to
name a few. Absinthe was first produced commercially in 1797 by Henry-Louis Pernod, who purchased the formula from a French exile
living in Switzerland. The wormwood, Artemisia absinthium, is the chief flavouring ingredient of absinthe and the presence of the
monoterpene thujone in this drug was the reason for the prohibition of the production and sale of absinthe in many countries. Thujone
is a toxic chemical present in wormwood and is responsible for the pharmacological and toxicological properties of absinthe.
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